Technical documents / Glutathione / sds
GlutathioneSafety data sheet (SDS)
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Laboratory research use only. Not a medicinal product, not for human or veterinary use, not for diagnosis, treatment, food, dietary supplement, or cosmetic use.
1. Identification
Product identifier: L-Glutathione, reduced (GSH)
Synonyms: GSH; reduced glutathione; γ-L-glutamyl-L-cysteinylglycine; 还原型谷胱甘肽
Recommended use: Laboratory research reagent.
Restrictions on use: Laboratory research use only. Not a medicinal product, not for human or veterinary use, not for diagnosis, treatment, food, dietary supplement, or cosmetic use.
- Supplier: BIOSWISS, UNIPESSOAL LDA (Veniscy catalog)
- Address: Rua Castilho, 14C, 5º, 1250-069 Lisboa, Portugal
- Email: orders@veniscy.com
2. Hazard identification
OSHA HCS classification: Not classified as hazardous based on available information. Complete toxicological data are not available; handle as a potentially hazardous research chemical.
GHS: No pictogram or signal word required based on available information. Dry powder may cause mechanical irritation to eyes, skin, or respiratory tract.
Precautions: Avoid breathing dust. Avoid contact with eyes, skin, and clothing. Wear laboratory gloves, eye protection, and a lab coat. Use adequate ventilation. Wash hands after handling. Prevent release to the environment.
Other hazards: Contains a free thiol (–SH). Reducing agent. Sensitive to air and moisture (oxidizes to GSSG). Dry powder may irritate. Toxicological data are incomplete.
3. Composition
| Component | CAS | Concentration |
|---|---|---|
| L-Glutathione, reduced (GSH) | 70-18-8 | ≥ 98% or as specified on the batch COA |
Formula: C10H17N3O6S
Molecular weight: 307.32 g/mol
Water, residual solvent, salt/counterion, and oxidized glutathione (GSSG) may be present within specification.
4. First-aid measures
Inhalation: Move to fresh air. If breathing is difficult, seek medical attention.
Skin: Remove contaminated clothing. Wash with water and soap. Seek medical attention if irritation develops.
Eyes: Rinse cautiously with water for at least 15 minutes. Remove contact lenses if easy to do. Seek medical attention if irritation persists.
Ingestion: Rinse mouth. Do not induce vomiting unless directed by medical personnel. Seek medical advice.
Symptoms: No specific human health data. Dust may cause irritation.
5. Fire-fighting measures
Suitable extinguishing media: Water spray, alcohol-resistant foam, dry chemical, or carbon dioxide.
Unsuitable: Do not use a direct water jet if it may spread material.
Specific hazards: Thermal decomposition may produce carbon oxides, nitrogen oxides, sulfur oxides, and irritating fumes.
Protective equipment: Self-contained breathing apparatus and full protective gear.
6. Accidental release measures
Avoid dust. Wear gloves, lab coat, and eye protection. Ventilate. Collect solid with methods that minimize dust, label the container, and dispose of as chemical waste. Clean with water or laboratory detergent. Keep out of drains.
7. Handling and storage
Handle only in a laboratory by trained personnel. Avoid dust. Do not taste or swallow. Do not use in humans or animals. Do not use for diagnostic or therapeutic applications.
Storage: −20 °C, protected from light, air, and moisture (thiol oxidizes). Allow the closed container to reach room temperature before opening to reduce condensation. Keep away from incompatible materials.
8. Exposure controls / personal protection
Exposure limits: No OSHA PEL, ACGIH TLV, or NIOSH REL established for this product.
Engineering: Chemical fume hood or local exhaust when handling powder.
Eye: Safety glasses with side shields or goggles. Skin: nitrile gloves and lab coat.
Respiratory: Not normally required with adequate ventilation. Use a NIOSH-approved particulate respirator if dust cannot be controlled.
9. Physical and chemical properties
| Property | Value |
|---|---|
| Appearance | White to off-white crystalline powder |
| Odor | Odorless to faint sulfurous |
| pH | Approx. 2.5–3.5 (10 mg/mL aqueous); verify COA |
| Melting | Approx. 189–195 °C with decomposition |
| Solubility | Freely soluble in water; practically insoluble in ethanol/ether |
| Partition coefficient | log P approx. −4.5 (estimated) |
10. Stability and reactivity
Reactivity: Reducing agent. Reacts with oxidizers. The free thiol oxidizes in air to glutathione disulfide (GSSG).
Chemical stability: Stable when cold, dry, and protected from air/light. Sensitive to oxygen, moisture, heat, and metal ions.
Hazardous reactions: Not expected under normal laboratory handling.
Avoid: Heat, moisture, direct light, dust generation, repeated freeze–thaw.
Incompatible: Strong oxidizers, strong acids, strong bases.
Hazardous decomposition: Thermal decomposition may produce carbon oxides, nitrogen oxides, sulfur oxides, and irritating fumes.
11. Toxicological information
Acute toxicity, irritation, sensitization, mutagenicity, carcinogenicity, reproductive toxicity, STOT, and aspiration: no complete data for this research material. Handle as a compound of unknown toxicity. Avoid inhalation, ingestion, injection, and contact with skin or eyes.
12. Ecological information
Ecotoxicity, degradability, bioaccumulation, and soil mobility: no data available. Prevent release to drains, soil, or surface water.
13. Disposal considerations
Dispose through a licensed chemical-waste contractor under applicable law. Do not discharge to drains. Empty containers may retain residue.
14. Transport information
DOT / IATA / IMDG: Not regulated as dangerous goods based on available information. UN number: not applicable.
If dry ice is used as refrigerant, classify and declare dry ice separately as UN1845 where required.
15. Regulatory information
BIOSWISS, UNIPESSOAL LDA supplies this material only as a laboratory research reagent. It is not intended as a drug, biological product, medical device, diagnostic, food, dietary supplement, cosmetic, or consumer product.
Importer and user must verify FDA/EMA/TSCA/state and import rules for actual use, form, and volume.
16. Other information
Published by BIOSWISS, UNIPESSOAL LDA for the Veniscy catalog. OSHA 16-section format. Format reference: 29 CFR 1910.1200. Laboratory research use only. Not a medicinal product, not for human or veterinary use, not for diagnosis, treatment, food, dietary supplement, or cosmetic use.
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